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℡ 4000-520-616
℡ 4000-520-616
Mabtech/anti-human IL-12/-23 (p40) mAbs MT86/221, purified/3450-3-250/250 µg
产品编号:3450-3-250
市  场 价:¥4100.00
场      地:美国(厂家直采)
产品分类: 抗体类>一抗>功能性抗体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$205.00
品      牌: Mabtech
公      司:Mabtech
公司分类:
Mabtech/anti-human IL-12/-23 (p40) mAbs MT86/221, purified/3450-3-250/250 µg
商品介绍
MonoclonalantibodiesspecificforIL-12/-23(p40)

Thesemonoclonalantibodiesarespecificforthep40subunitofIL-12andIL-23.CombinewithdifferentdetectionantibodiesforsensitiveandspecificdetectionofhumanIL-12(p70),IL-12/-23(p40)andIL-23.

WerecommendMT86/221ascaptureantibodiesinELISAandELISpot.CombinewithmAbMT704fordetectionofIL-12(p70),withmAbMT618fordetectionofIL-12/-23(p40)andwithmAbMT155fordetectionofIL-23.SeeRelatedproducts.

MoreinformationaboutMabtech"smonoclonalantibodiestoIL-12andIL-23:seeAdditionalinfo.

Speciescross-reactivity

Themonoclonalantibodiescross-reactwiththep40subunitofIL-12andIL-23fromnon-humanprimates.SeetheHuman/NHPcross-reactivitytable.


AnalyteInformation

IL-12(p70)
Interleukin-12(IL-12,IL12)is,whenBIOLOGicallyactive,aheterodimer(p70)consistingoftwocovalentlylinkedsubunits,p35andp40.Thep40subunitissharedwithIL-23.IL-12isproducedbyantigen-presentingcells,specificallydendriticcellsandmacrophages.IL-12isaproinflammatorycytokinethatpromotesTH1-typeresponsesbyinducingIFN-γproductionandenhancingproliferationandcytotoxicityofNKandTcells.

IL-12/-23(p40)
Interleukin-12(IL-12,IL12)is,whenbiologicallyactive,aheterodimer(p70)consistingoftwocovalentlylinkedsubunits,p35andp40.IL-12isproducedbyantigen-presentingcells,specificallydendriticcellsandmacrophages.IL-12isaproinflammatorycytokinethatpromotesTh1-typeresponsesbyinducingIFN-γproductionandenhancingproliferationandcytotoxicityofNKandTcells.Interleukin-23(IL-23)isadisulfide-linkedheterodimerwhichconsistsofauniquep19subunitandthep40subunitofIL-12.IL-23isaproinflammatorycytokine,whichisproducedbymacrophagesanddendriticcellsuponinfectionswithcertainpathogens.TheIL-23receptorisexpressedonTh17cellsandIL-23isresponsIBLeforTh17expansionandstABIlization.SincebothIL-12andIL-23heterodimerscomprisethep40subunit,captureimmunoassaysbasedonantibodiestop40willdetectbothcytokines.Suchassayscanalsodetectp40monomersanddimers.

IL-23
Interleukin-23(IL-23,IL23)isadisulfide-linkedheterodimerwhichconsistsofauniquep19subunitandthep40subunitofIL-12.IL-23isaproinflammatorycytokine,whichisproducedbymacrophagesanddendriticcellsuponinfectionswithcertainpathogens.TheIL-23receptorisexpressedonTh17cellsandIL-23isresponsibleforTh17expansionandstabilization.

Application:
  • ELISA
  • ELISpot
Reactivity:
  • Human/NHP
Format:Purified
Specificity:Nativeandrecombinantp40subunitofIL-12andIL-23.Theantibodiesrecognizep40monomer,p40homodimer,IL-12p70heterodimer(p40+p35)andIL-23heterodimer(p40+p19).
Isotype:MouseIgG1
Contents:
  • MT86/221,purified,suppliedat0.5mg/mlinPBSwith0.02%sodiumazide
Size:250µg
VeryeasytouseELISAkit.
品牌介绍

   Mabtech 公司于1986年创办于瑞典斯德哥尔摩大学免疫学系,是一家欧洲的集研究,开发,销售,技术支持为一体的高科技免疫生物技术公司。Mabtech公司始终专业致力于研发新的单克隆抗体,生产创新的免疫试剂和销售高品质的全配套的免疫试剂盒。公司核心业务是致力于优化发展酶联免疫斑点法技术 (ELISpot)、荧光免疫斑点法技术 (FluoroSpot) 和酶联免疫吸附试验技术 (ELISA) 等免疫学方法。Mabtech公司的产品质量体系符合ISO 9001和ISO 13485国际标准。

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