Thesemonoclonalantibodiesarespecificforthep40subunitofIL-12andIL-23.CombinewithdifferentdetectionantibodiesforsensitiveandspecificdetectionofhumanIL-12(p70),IL-12/-23(p40)andIL-23.
WerecommendMT86/221ascaptureantibodiesinELISAandELISpot.CombinewithmAbMT704fordetectionofIL-12(p70),withmAbMT618fordetectionofIL-12/-23(p40)andwithmAbMT155fordetectionofIL-23.SeeRelatedproducts.
MoreinformationaboutMabtech"smonoclonalantibodiestoIL-12andIL-23:seeAdditionalinfo.
Themonoclonalantibodiescross-reactwiththep40subunitofIL-12andIL-23fromnon-humanprimates.SeetheHuman/NHPcross-reactivitytable.
IL-12(p70)
Interleukin-12(IL-12,IL12)is,whenBIOLOGicallyactive,aheterodimer(p70)consistingoftwocovalentlylinkedsubunits,p35andp40.Thep40subunitissharedwithIL-23.IL-12isproducedbyantigen-presentingcells,specificallydendriticcellsandmacrophages.IL-12isaproinflammatorycytokinethatpromotesTH1-typeresponsesbyinducingIFN-γproductionandenhancingproliferationandcytotoxicityofNKandTcells.
IL-12/-23(p40)
Interleukin-12(IL-12,IL12)is,whenbiologicallyactive,aheterodimer(p70)consistingoftwocovalentlylinkedsubunits,p35andp40.IL-12isproducedbyantigen-presentingcells,specificallydendriticcellsandmacrophages.IL-12isaproinflammatorycytokinethatpromotesTh1-typeresponsesbyinducingIFN-γproductionandenhancingproliferationandcytotoxicityofNKandTcells.Interleukin-23(IL-23)isadisulfide-linkedheterodimerwhichconsistsofauniquep19subunitandthep40subunitofIL-12.IL-23isaproinflammatorycytokine,whichisproducedbymacrophagesanddendriticcellsuponinfectionswithcertainpathogens.TheIL-23receptorisexpressedonTh17cellsandIL-23isresponsIBLeforTh17expansionandstABIlization.SincebothIL-12andIL-23heterodimerscomprisethep40subunit,captureimmunoassaysbasedonantibodiestop40willdetectbothcytokines.Suchassayscanalsodetectp40monomersanddimers.
IL-23
Interleukin-23(IL-23,IL23)isadisulfide-linkedheterodimerwhichconsistsofauniquep19subunitandthep40subunitofIL-12.IL-23isaproinflammatorycytokine,whichisproducedbymacrophagesanddendriticcellsuponinfectionswithcertainpathogens.TheIL-23receptorisexpressedonTh17cellsandIL-23isresponsibleforTh17expansionandstabilization.
Application: |
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Reactivity: |
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Format: | Purified |
Specificity: | Nativeandrecombinantp40subunitofIL-12andIL-23.Theantibodiesrecognizep40monomer,p40homodimer,IL-12p70heterodimer(p40+p35)andIL-23heterodimer(p40+p19). |
Isotype: | MouseIgG1 |
Contents: |
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Size: | 250µg |
Otherformats: | ClicktoviewallHuman/NHPIL-12(p70),IL-12/-23(p40),IL-23products |
VeryeasytouseELISAkit.
品牌介绍
Mabtech 公司于1986年创办于瑞典斯德哥尔摩大学免疫学系,是一家欧洲的集研究,开发,销售,技术支持为一体的高科技免疫生物技术公司。Mabtech公司始终专业致力于研发新的单克隆抗体,生产创新的免疫试剂和销售高品质的全配套的免疫试剂盒。公司核心业务是致力于优化发展酶联免疫斑点法技术 (ELISpot)、荧光免疫斑点法技术 (FluoroSpot) 和酶联免疫吸附试验技术 (ELISA) 等免疫学方法。Mabtech公司的产品质量体系符合ISO 9001和ISO 13485国际标准。
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